Peer-reviewed work on inflammatory biomarkers and cerebral small vessel disease. Each entry links to the publisher of record. We do not host article text or reproduce figures.
Provenance and disclosure
Jason D. Hinman, MD, PhD, is the founder of Sage Cerebro, serves on its board, and holds equity in the company. He is an author on each of the studies below. The work was carried out in his academic laboratory and the resulting intellectual property is licensed to Sage Cerebro. These studies concern the biology of inflammatory biomarkers and their association with cerebrovascular findings. They were not designed to evaluate SageSignal, and nothing here is a claim about the performance of any Sage Cerebro product.
Stroke2024Composite score
Association of incident stroke risk with an IL-18-centered inflammatory network biomarker composite
Martirosian RA, Wiedner C, and colleagues.
Stroke, 2024. PMID 38690658
The authors state their aim as to "validate the association of this inflammatory biomarker network with incident stroke risk, cognitive impairment, and imaging metrics in a sample of the Framingham Offspring Cohort." The sample comprised 2,201 adults followed across roughly two decades.
An IL-18-centered inflammatory network as a biomarker for cerebral white matter injury
Altendahl M, Maillard P, Harvey D, Cotter D, Walters S, Wolf A, and colleagues.
PLOS ONE, 2020;15(1):e0227835
Describes MPO, GDF-15, RAGE, ST2, IL-18 and MCP-1 as a biologically interconnected network, and reports the association of a composite of the six with imaging measures of white matter injury across two cohorts.
Plasma lipid profiling identifies biomarkers of cerebral microvascular disease
Azizkhanian I, Sheth SA, Iavarone AT, Lee S, Kakarla V, Hinman JD.
Frontiers in Neurology, 2019;10:950
Examines plasma sphingolipid species as blood-based markers of white matter hyperintensity burden in patients evaluated for acute neurological symptoms.
Placental growth factor as a sensitive biomarker for vascular cognitive impairment
Hinman JD, Elahi F, Chong D, Radabaugh H, Ferguson A, Maillard P, and colleagues.
Alzheimer's & Dementia, 2023. PMID 36815663
Examines placental growth factor as a blood-based marker of vascular cognitive impairment. Listed as related work by the same investigator: placental growth factor is not one of the six analytes in the SageSignal panel, and this study does not concern that panel.
Full text and figures are hosted by each publisher and remain their copyright. Sage Cerebro links to the record of publication and does not reproduce article content.
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