SageSignal At-home biomarker panel

Brain health, observed over time.

Six inflammatory biomarkers, measured from a blood sample you collect at home and read as one composite you can follow quarter over quarter. Access opens in stages.

Why these six

A reading that changes is a reading you can follow.

The six analytes in this panel are inflammatory signals. Published work describes them rising and falling together as a network rather than drifting independently, which is the reason a second reading tells you something a first one cannot.

That is why SageSignal is built around repeat testing, and why it reports a trend alongside each individual value.

What any particular change means for an individual is not established. Nothing here is medical advice.

What it measures

Six markers of inflammatory signalling.

Each of the six is a clinically recognized analyte studied in relation to cerebrovascular health. Together they form a composite reading you can follow across quarters rather than a single point in time.

IL-18
Interleukin-18
A pro-inflammatory cytokine at the centre of the marker network.
MCP-1
Monocyte chemoattractant protein-1
Immune signalling; recruits monocytes to sites of inflammation.
ST2
Soluble ST2
A marker of cellular stress and cardiovascular strain.
GDF-15
Growth differentiation factor 15
A metabolic marker that rises with cellular and metabolic stress.
RAGE
Receptor for advanced glycation end products
Associated with glycation and vascular signalling.
MPO
Myeloperoxidase
An indicator of oxidative balance and leukocyte activity.
The network

The six markers are biologically connected.

Published work describes these six analytes as an interconnected inflammatory network centred on IL-18, rather than six independent readings. That is the reason SageSignal reports a composite alongside the individual values.

The composite is a normalized average across the panel, so no single analyte drives the reading on its own.

See the published research
IL-18
MCP-1
ST2
GDF-15
RAGE
MPO
How it works

Three steps, no clinic visit.

Step 01

Collect at home

The kit uses a Tasso+ device that attaches to the upper arm. No finger pricks, and no phlebotomist.

Step 02

Laboratory analysis

Your sample is analyzed in a CLIA-certified laboratory. The six-marker panel runs as a single multiplex assay.

Step 03

Read the trend

Your report shows each marker against its reference range and a composite reading you can follow quarter over quarter.

Your report

You see the panel, and you see the trend.

Every marker is reported with its value, its unit, and where it sits relative to a reference population. The composite sits above them. Test again and the report keeps the history.

01 A population-normalized composite, not a pass or fail
02 Each of the six values, with units, in plain language
03 A quarter-over-quarter view once you have more than one
Composite score Illustrative
0.42 z-score
Reference population Q2 2026

IL-18Inflammatory signalling
214pg/mL
MCP-1Immune signalling
289pg/mL
ST2Cellular stress
18.4ng/mL
GDF-15Metabolic
1130pg/mL
RAGEGlycation
1042pg/mL
MPOOxidative balance
96ng/mL

Four quarters
Q3 25Q4 25Q1 26Q2 26

Illustrative example, not a real reading. Values shown are for layout only.

Where this comes from

The science is published, and it lives on its own page.

The biomarker panel draws on peer-reviewed work published by independent investigators in PLOS ONE and Frontiers in Neurology. We link to the journals rather than summarising them here.

That research concerns the biomarkers and the underlying cerebrovascular science. It is not a claim about the performance of any Sage Cerebro product.

Research and publications
Waitlist

Be among the first.

Name and email is all we ask. We will write when your place comes up, and we never ask health questions.

We use your details only to contact you about SageSignal availability. No health information is collected, and we do not sell or share personal information. See the privacy policy.